Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study
Main finding · Association of daily moderate to vigorous physical activity with progression, by risk groupResult — go to the resultHazard ratio per 10-min increase 0.920 95% CI 0.856–0.988Authors' conclusion
More daily minutes spent in moderate to vigorous physical activity was associated with a reduced risk of progression to type 1 diabetes in children aged 5-15 years who had developed multiple IAs.
Study context
- Population
- Genetically at-risk children aged 5–15 years in the TEDDY study
- Participants
- 3,869 / 302 / 294
- Exposure
- Daily minutes of moderate to vigorous physical activity
- Risk group 1n = 3,869
- Risk group 2n = 302
- Risk group 3n = 294
- Outcome
- Appearance of one or several autoantibodies and progression to T1D
Methodological detailslongitudinal, Cox proportional hazard models, annual accelerometry
- Longitudinal
- Cox proportional hazard models
- Annual accelerometry
Main finding
As reported in the abstract
Hazard ratio per 10-min increase
0.920
95% CI 0.856–0.988
P = 0.021
Events by group
Risk group 1
157
events
Risk group 2
73
events
Risk group 3
148
events
Observational data: associations, not effects.
Further findings
Progression to T1D in multiple islet autoantibody (IA)-positive children when GADA was the first autoantibody, per 10-min increase in daily moderate to vigorous physical activity
- HR per 10-min increase (95% CI 0.783, 0.996); P = 0.043
- 0.883
Appearance of first IA in IA-negative children (risk group 1) and of multiple IAs in single IA-positive children (risk group 2)
- No significant association in risk group 1 or risk group 2
Original publication
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