Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome
Authors' conclusion
These results offer insights into pain mechanisms in FD/MAS, while providing a basis for implementation of comprehensive pain management treatment approaches that addresses neuropsychological aspects of pain.
Study context
- Population
- Patients with fibrous dysplasia/McCune-Albright syndrome and age-sex matched healthy controls
- Participants
- 20 vs 16
- Comparison
- FD/MAS vs healthy controls
- FD/MASn = 20
- Healthy controlsn = 16reference
- Outcome
- Questionnaire responses, detection thresholds and tolerances to thermal stimuli, and structural and functional central nervous system (CNS) properties
Methodological detailssingle-site, age-sex matched healthy controls
- Single-site
- Age-sex matched healthy controls
Main finding
As reported in the abstract
- Pain severity in FD/MAS associated with more neuropathic pain quality, higher pain catastrophizing and depression
- Normal detection of nonnoxious stimuli in patients on quantitative sensory testing
- Higher pain tolerances in FD/MAS vs healthy controls
- Greater pain severity, neuropathic pain quality and psychological status associated with reduced white matter structural integrity (superior thalamic radiation, uncinate fasciculus), reduced gray matter thickness (pre-/paracentral gyri) and heightened responses to pain (precentral, temporal, frontal gyri)
Observational data: associations, not effects.
Original publication
Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome. J Clin Endocrinol Metab. Published 6 October 2023. doi:10.
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