Noninvasive Indices of MASLD Are Associated With Hypogonadism in Male Patients With Type 2 Diabetes Mellitus
Authors' conclusion
We found an association between noninvasive indices of steatosis and hypogonadism in patients with T2DM. These indices could be used to direct the patients to andrological evaluation.
Study context
- Population
- Men with T2D without history of liver diseases and alcoholism, recruited on an outpatient basis
- Participants
- 189 men
- Exposure
- Low testosterone vs normal testosterone
- Outcome
- Comparison of steatosis (FLI, HSI, DSI) and fibrosis (APRI, FIB-4) indices with testosterone levels and presence of hypogonadism
Methodological detailsoutpatient
- Outpatient
Main finding
As reported in the abstract
Noninvasive steatosis indices by testosterone status
| Group | Value | FLI | HSI | DSI |
|---|---|---|---|---|
| Low testosterone | 74.1 (range or IQR as printed 61.4–93.5) | 74.1 [61.4-93.5] | 41.5 [39.2-45.9] | 0.45 [−0.08-+1.04] |
| Normal testosterone | 56.5 (range or IQR as printed 32.1–78.2) | 56.5 [32.1-78.2] | 40.1 [36.6-43.2] | −0.07 [−1.02-+0.58] |
Value
Low testosterone74.1 (range or IQR as printed 61.4–93.5)
Normal testosterone56.5 (range or IQR as printed 32.1–78.2)
FLI
Low testosterone74.1 [61.4-93.5]
Normal testosterone56.5 [32.1-78.2]
HSI
Low testosterone41.5 [39.2-45.9]
Normal testosterone40.1 [36.6-43.2]
DSI
Low testosterone0.45 [−0.08-+1.04]
Normal testosterone−0.07 [−1.02-+0.58]
- Low testosterone vs Normal testosterone: P < 0.001 — higher with low testosterone
- Low testosterone vs Normal testosterone: P = 0.005 — higher with low testosterone
- Low testosterone vs Normal testosterone: P < 0.001 — higher with low testosterone
Observational data: associations, not effects.
Further findings
Prediction of low total testosterone (TT) (ROC)
- FLI ≥63 best predictive index of low TT: sensitivity
- 73%
- FLI ≥63: specificity
- 64%
Clinical symptoms of hypogonadism
- FLI and DSI correlated with clinical symptoms of hypogonadism
Original publication
Noninvasive Indices of MASLD Are Associated With Hypogonadism in Male Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 5 October 2023. doi:10.
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