Perspectives on antibiotic management of diabetic foot osteomyelitis: A scoping review on routes of administration
Authors' conclusion
Current data suggest that oral antibiotic therapy may be a safe and effective alternative to IV therapy in selected patients with DFO, though substantial evidence gaps remain beyond infection management.
Study context
- Population
- Studies of antibiotic administration routes for diabetic foot osteomyelitis (DFO); mainly adults with diabetic foot infection or DFOstudies, of 6814 records
- Participants
- 25 studies
- Comparison
- Oral vs intravenous (IV) antibiotics
- Outcome
- Clinical outcomes
Methodological detailsJoanna Briggs Institute methodological framework, quintuple aim for quality of care, two independent interdisciplinary reviewers
- Joanna Briggs Institute methodological framework
- Quintuple aim for quality of care
- Two independent interdisciplinary reviewers
Main finding
As reported in the abstract
Studies mainly retrospective observational
76 %
Studies including adults with diabetic foot infection or DFO
68 %
Further findings
Evidence gaps
- Data on patient-reported outcomes and experience, team management, equity factors and standardized definitions of clinical endpoints largely scarce
Original publication
Perspectives on antibiotic management of diabetic foot osteomyelitis: A scoping review on routes of administration. Diabetes Res Clin Pract. Published 4 December 2025. doi:10.
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