Perioperative Desaturation and Postoperative Nausea or Vomiting Requiring Antiemetic Administration in Glucagon‐Like Peptide‐1 Receptor Agonist Users Undergoing Ambulatory Ophthalmic Surgery Under Mild‐To‐Moderate Sedation: A Large Retrospective Cohort Study
Main finding · Desaturation <90%Result — go to the resultOdds ratio 1.22 95% CI 0.38–3.88Authors' conclusion
In this cohort, no desaturation events occurred, although PONV was more frequent amongst GLP-1RA users.
Study context
- Population
- Adults undergoing ambulatory ophthalmic surgery under mild-to-moderate sedation, Kensington Eye Institute, January 2022–December 2024
- Participants
- 30,328 adults45,636 visits
- Exposure
- GLP-1 RA users vs non-users
- GLP-1RA usersn = 1,036
- Outcome
- Desaturation < 90% and PONV requiring antiemetic administration
Methodological detailsobservational, multivariable logistic regression with generalized estimating equation (GEE)
- Observational
- Multivariable logistic regression with GEE
Main finding
Desaturation <90% · perioperative
Odds ratio
1.22
95% CI 0.38–3.88
P = 0.74
GLP-1 RA usersvs non-users
OR 1.22 (95% CI 0.38–3.88); P = 0.74
As reported in the abstract
Observational data: associations, not effects.
Further findings
PONV requiring antiemetic administration (co-primary outcome) · postoperative
| OR (95% CI) | P value | ||
|---|---|---|---|
| GLP-1RA useCo-primary outcome | 1.93 (1.29–2.89) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- PONV requiring antiemetic administration (co-primary outcome): GLP-1RA users vs non-users; multivariable GEE logistic regression
PONV requiring antiemetic administration (co-primary outcome) · postoperative
- GLP-1RA use associated with increased likelihood of PONV requiring antiemetics
Safety
Events
| Outcome | GLP-1RA users | Non-users |
|---|---|---|
| Perioperative or 24-h postoperative aspiration | 0 | 0 |
Original publication
Perioperative Desaturation and Postoperative Nausea or Vomiting Requiring Antiemetic Administration in Glucagon‐Like Peptide‐1 Receptor Agonist Users Undergoing Ambulatory Ophthalmic Surgery Under Mild‐To‐Moderate Sedation: A Large Retrospective Cohort Study. Diabetes Obes Metab. Published 8 June 2026. doi:10.
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