Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes
Authors' conclusion
The findings of this study suggest an increase in brain aging among individuals with T1D without any early signs of AD-related neurodegeneration. These increases were associated with reduced cognitive performance, but overall, the abnormal patterns seen in this sample were modest, even after a mean of 38 years with T1D.
Study context
- Population
- Middle- and older-aged adults with T1D from Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC); median (range) age 60 (44–74) years, median diabetes duration 37 (30–51) years
- Participants
- 416 vs 99
- Exposure
- T1D vs adults without diabetes
- EDICn = 416
- Controlsn = 99reference
- Outcome
- MRI and machine learning indices of brain age and AD-like atrophy; psychomotor and mental efficiency; immediate memory
Methodological detailsMagnetic resonance imaging (MRI) ancillary study of the DCCT/EDIC cohort, 27 clinical centers in the US and Canada, Data analyses July 2020 to April 2022, Cross-sectional MRI data collected 2018 to 2019, related to factors measured longitudinally in DCCT/EDIC
- MRI ancillary study of the DCCT/EDIC cohort
- 27 clinical centers in the US and Canada
- Data analyses July 2020 to April 2022
- Cross-sectional MRI data collected 2018 to 2019, related to factors measured longitudinally in DCCT/EDIC
Main finding
As reported in the abstract
Brain age
EDIC
6.16
β · SE 0.71
Controls
1.04
β · SE 0.04
P < 0.001
Observational data: associations, not effects.
Further findings
- EDIC: greater brain age associated with lower psychomotor and mental efficiency (β, SE 0.01, P < .001)
- −0.04
- Controls: no association
Original publication
Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes. JAMA Netw Open. Published 1 June 2023. doi:10.
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