Pancreatic polypeptide in patients with type 1 diabetes and exocrine failure or chronic pancreatitis. The DIAPP study
Authors' conclusion
. - PP secretion was altered specifically in patients with CP, not in T1D, even when associated with pancreatic exocrine failure.
Study context
- Population
- Patients with T1D (with normal pancreatic function or exocrine failure) or type 3c diabetes with chronic pancreatitis; all had a mixed meal test with C-peptide and pancreatic polypeptide (PP) measured before and at 60, 90 and 120 minutes
- Participants
- 7 / 9 / 13
- Exposure
- T1D with normal pancreatic function vs T1D with exocrine failure vs chronic pancreatitis (type 3c diabetes)
- T1DNn = 7
- T1D and exocrine failure (T1DEF)n = 9
- Chronic pancreatitis (CP)n = 13
- Outcome
- PP secretion (AUC of PP) during a mixed meal test
- Follow-up
- Before and at 60, 90 and 120 minutes
Main finding
As reported in the abstract
AUC of PP during mixed meal test (AUCPP)
- CP vs T1DN: P < 0.01
- CP vs T1DEF: P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| AUC of C-peptide during mixed meal test (AUCCpep)CP vs T1DEF · AUCCpep significantly greater in CP | P < 0.0001 |
| AUC of C-peptide during mixed meal test (AUCCpep)CP vs T1DN · AUCCpep significantly greater in CP | P < 0.001 |
| AUCPP / AUCCpep ratioCP vs T1DN · ratio higher in CP | P < 0.0001 |
| AUCPP / AUCCpep ratioCP vs T1DEF · ratio higher in CP | P < 0.0001 |
Original publication
Pancreatic polypeptide in patients with type 1 diabetes and exocrine failure or chronic pancreatitis. The DIAPP study. Diabetes Metab. Published 9 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →