Pancreatic imaging in MEN1—comparison of conventional and somatostatin receptor positron emission tomography/computed tomography imaging in real-life setting
Authors' conclusion
SSTR PET/CT demonstrates high accuracy in the detection of panNETs and alters the clinical management in nearly half of the MEN1-patients. SSTR PET/CT enables timely diagnosis and staging of MEN1-related panNETs.
Study context
- Population
- Patients with MEN1, median age 40 (range 16–72) years; SSTR PET/CT as screening regardless of disease stage or to characterise known pancreatic neuroendocrine tumors (panNETs)or to characterise known panNETs 11
- Participants
- 58 patients
- Comparison
- SSTR PET/CT vs conventional imaging
- Outcome
- panNET detection
Methodological detailsreal-life setting, blinded analysis, Median follow-up 47 months
- Real-life setting
- Blinded analysis
- Median follow-up 47 months
Performance
As reported in the abstract
- SSTR PET/CT detected three times as many panNETs as conventional imaging
- SSTR PET/CT vs Conventional imaging: P < 0.001
Further findings
- panNET or recurrence identified in patients with no previous panNET (n = 22) or in remission after surgery (n = 3) — SSTR PET/CT
- 60%
- Management altered by SSTR PET/CT
- 47% · 27 events
- Management altered by SSTR PET/CT — Referred for surgery
- 7 (12%)
- Management altered by SSTR PET/CT — Received systemic treatment
- 5 (9%)
- panNET or recurrence identified in patients with no previous panNET (n = 22) or in remission after surgery (n = 3) — panNET identified
- 14
- panNET or recurrence identified in patients with no previous panNET (n = 22) or in remission after surgery (n = 3) — Recurrence identified
- 1
- panNET or recurrence identified in patients with no previous panNET (n = 22) or in remission after surgery (n = 3): 15/25
panNET on SSTR PET/CT not immediately visible on conventional imaging · median follow-up 47 months
- Patients with panNET revealed only by SSTR PET/CT
- 8
- Became visible on conventional imaging during follow-up
- 3
- Required intervention
- 0
panNETs on conventional imaging after negative SSTR PET/CT · 38 months of follow-up
- No panNETs identified on conventional imaging when SSTR PET/CT was negative
Original publication
Pancreatic imaging in MEN1—comparison of conventional and somatostatin receptor positron emission tomography/computed tomography imaging in real-life setting. Eur J Endocrinol. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →