Oxytocin-induced changes in free T3/free T4 ratio and relationship with quality of life in adults with obesity
Authors' conclusion
Prolonged OXT vs placebo increased fT3/fT4 and impacted the relationship between fT3/fT4 and MHQoL changes, with a trend-level positive correlation between fT3/fT4 and MHQoL change scores.
Study context
- Population
- Adults with obesity, tertiary academic center
- Participants
- 61 adults
- Comparison
- Intranasal oxytocin (OXT) vs placebo
- Primary endpoint
- Pre- and posttreatment fasting thyroid hormones (fT3/fT4 ratio) and relationship with MHQoL changes
- Follow-up
- Week 6 (thyroid hormones); week 8 (MHQoL)
Methodological details8-week, tertiary academic center
- 8-week
- Tertiary academic center
Primary result
As reported in the abstract
fT3/fT4 ratio change · 6 weeks
- Increase in fT3/free T4 (fT4) in OXT
- P = .048
- No change in fT3/fT4 in placebo
- P = .406
Further findings
- Relationship between fT3/fT4 change (6 weeks) and MHQoL change (8 weeks) — Increased fT3/fT4 positively associated with MHQoL improvement
- trend-level P = .088 · treatment × Δ[fT3/fT4] P = .023
TSH, fT4 and fT3 · 6 weeks
- TSH, fT4 and fT3 did not change
- P ≥ 0.154
Original publication
Oxytocin-induced changes in free T3/free T4 ratio and relationship with quality of life in adults with obesity. J Clin Endocrinol Metab. Published 9 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →