Overweight or obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: a Bayesian survival analysis from the Hunter Community Study
Authors' conclusion
There was increased risk of CVD in older adults with overweight or obesity, even in the absence of any metabolic abnormality. This argues against the notion of 'metabolically healthy' overweight or obesity.
Study context
- Population
- Community-dwelling older men and women without known cardiovascular disease (CVD) and with body mass index (BMI) ≥ 18.5 kg m², Newcastle, New South Wales, Australia; stratified into six BMI-metabolic health categories
- Participants
- 2,313 men
- Exposure
- BMI-metabolic health categories vs metabolically healthy normal weight
- Outcome
- Incident physician-diagnosed CVD (fatal or nonfatal MI, fatal or nonfatal stroke, angina, or coronary revascularisation), by linkage to hospital admissions and Medicare Australia data
- Follow-up
- Median 9.7 years
Methodological detailsBayesian survival analysis, informative prior from a previously published meta-analysis
- Bayesian survival analysis
- Informative prior from a previously published meta-analysis
Main finding
As reported in the abstract
Incident CVD · median follow-up 9.7 years
Each group vs metabolically healthy normal weightHazard ratio (95% CrI)
Metabolically healthy overweight
1.52(0.96–2.36)
Metabolically healthy obesity
1.86(1.14–3.08)
- Incident CVD events
- 283
Observational data: associations, not effects.
Secondary outcomes
CVD-related deaths and all-cause deaths · median follow-up 9.7 years
- CVD-related deaths
- 58
- Deaths from any cause
- 277
Original publication
Overweight or obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: a Bayesian survival analysis from the Hunter Community Study. Int J Obes (Lond). Published 9 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →