Dynamics of adipose tissue macrophage populations after gastric bypass surgery
Authors' conclusion
The effect of gastric bypass on adipose tissue inflammatory status associates closely with CLS density even in subjects with suboptimal weight loss. The study suggests that factors related to bypass surgery other than weight loss modify the inflammatory response in adipose tissue.
Study context
- Population
- Patients with obesity; subcutaneous adipose tissue samples before and 12 months after intervention
- Participants
- 39 vs 43
- Comparison
- RYGB vs conservative treatment of obesity
- RYGBn = 39
- Conservativen = 43reference
- Outcome
- Dynamics of macrophage infiltration (CLS density, single macrophages) in subcutaneous adipose tissue
- Follow-up
- 12 months
Main finding
As reported in the abstract
CLS density per 1000 fat cells after RYGB · before to 12 months after surgery
- Crown-like structures (CLS) density declined from 4.1 (SD 3.5) to 1.1 (SD 0.8) per 1000 fat cells, regardless of degree of weight loss
- p < 0.000
Observational data: associations, not effects.
Original publication
Dynamics of adipose tissue macrophage populations after gastric bypass surgery. Obesity (Silver Spring). Published 7 December 2022. doi:10.
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