Outcomes in Maternal Graves' Disease: A Population-Based Mother–Infant Dyad Cohort Study
Authors' conclusion
Neonatal thyroid function levels were affected by maternal Graves' disease only when the disease was active during gestation. Moreover, maternal Graves' disease was also associated with an increased risk of adverse outcomes for the mother-infant dyad.
Study context
- Population
- Mother–term infant dyads born 2011–2021, Israeli thyroid newborn screening (NBS) linked with a tertiary medical center
- Participants
- 103,899 mother-infant dyads
- Exposure
- Mothers with past or active GD vs mothers without GD
- GDn = 292
- Outcome
- NBS total thyroxine (tT4) levels
Methodological detailslinked national NBS and tertiary medical center electronic records, MDClone big data platform
- Linked national NBS and tertiary medical center electronic records
- MDClone big data platform
Main finding
As reported in the abstract
- NBS total thyroxine (tT4) in infants of mothers with active GD higher than in the general Israeli population
- p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Assisted reproductive technology useGDvs No GD | 1.46 (1.03–2.07) | P = 0.031 | |
| Gestational hypertensionGDvs No GD | 3.53 (1.92–6.47) | P < 0.001 | |
| ProteinuriaGDvs No GD | 3.03 (1.43–6.45) | P = 0.004 | |
| Cesarean sectionGDvs No GD | 1.46 (1.13–1.90) | P = 0.004 | |
| Prelabor rupture of membranesGDvs No GD | 4.3 (3.13–5.91) | P < 0.001 | |
| Placental abnormalitiesGDvs No GD | 2.64 (1.57–4.44) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| Assisted reproductive technology useGD vs No GD · more frequent with GD | P = 0.012 |
| Gestational hypertensionGD vs No GD · more with GD | P < 0.001 |
| ProteinuriaGD vs No GD · more with GD | P < 0.001 |
| Cesarean sectionGD vs No GD · more with GD | P = 0.029 |
| Prelabor rupture of membranesGD vs No GD · more with GD | P < 0.001 |
| Placental abnormalitiesGD vs No GD · more with GD | P < 0.001 |
| Infant adjusted birthweight z-scoreLower in infants of mothers with GD | P = 0.007 |
| Infant small for gestational ageMore likely in infants of mothers with GD | P = 0.005 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Outcomes in Maternal Graves' Disease: A Population-Based Mother–Infant Dyad Cohort Study. Thyroid. Published 18 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →