Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes
Authors' conclusion
OCN is inversely associated with unhealthy AT, supporting the protective role of OCN in AT. Moreover, lower OCN levels are associated with increased CVR in AD population.
Study context
- Population
- People with autoimmune diabetes (AD) in a primary CV prevention population
- Participants
- 62 people
- Outcome
- Association of OCN with upper body fat deposition index (UBDFI)
Main finding
As reported in the abstract
Osteocalcin (OCN) inversely associated with UBDFI, adjusted β coefficient
−0.484
p value = 0.001
Observational data: associations, not effects.
Further findings
OCN and medium/high CV risk category (ST1RE score)
- OR per 1 SD increase in OCN for medium/high Cardiovascular risk (CVR) category (logistic regression)
- 0.541 [0.264--1.108], 95 % CI, p = 0.093
- People in medium/high CV risk categories had higher UBFDI and lower OCN
- Biomarkers of endothelial dysfunction not different across CVR classes
Original publication
Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes. Diabetes Res Clin Pract. Published 24 March 2025. doi:10.
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