Global, regional and country‐specific burden of chronic kidney disease due to type 1 diabetes mellitus: A systematic analysis of the 2021 global disease burden study
Authors' conclusion
CKD-T1DM poses a growing public health threat, necessitating region-specific strategies that address healthcare inequities, promote early screening and prioritise nephroprotective therapies among T1DM populations.
Study context
- Population
- Global population, chronic kidney disease (CKD) due to T1D (CKD due to T1DM (CKD-T1DM)), 2021, by GBD super regions and countries
- Outcome
- Incidence, prevalence, deaths and DALYs (age-standardised rates) of CKD-T1DM
- Follow-up
- 2021
Methodological detailsage-standardised rates, linear regression for temporal trends, age-period-cohort and Bayesian age-period-cohort (APC) projection models, sensitivity analysis with ARIMA and exponential smoothing models
- Age-standardised rates
- Linear regression for temporal trends
- Age-period-cohort and Bayesian APC projection models
- Sensitivity analysis with ARIMA and exponential smoothing models
Main finding
As reported in the abstract
Global burden of CKD-T1DM
Incident cases
95 140
Prevalent cases
6 295 711
Deaths
94 020
DALYs
3 875 628
Observational data: associations, not effects.
Further findings
Distribution of burden
- Males and young-to-middle-aged individuals more likely affected
- Middle-SDI regions at higher risk
- Considerable variation across GBD super regions and countries
Temporal trends and projections · 1990–2021; projection to 2046
- Number of patients with CKD-T1DM surged globally from 1990 to 2021
- Projected continuous increase until 2046, driven by ageing populations and unmet therapeutic needs in low-resource settings
Original publication
Global, regional and country‐specific burden of chronic kidney disease due to type 1 diabetes mellitus: A systematic analysis of the 2021 global disease burden study. Diabetes Obes Metab. Published 21 March 2025. doi:10.
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