Oral or injectable semaglutide for the management of type 2 diabetes in routine care: A multicentre observational study comparing matched cohorts
Authors' conclusion
In a real-world setting, improvements in HbA1c and body weight were similar after initiation of oral or injectable semaglutide. These results may be specific to the features of the matched cohorts under investigation, with limited generalizability to populations with different characteristics.
Study context
- Population
- New users of semaglutide with T2D from a cohort of 14,079 GLP-1 RA initiators; on average 63.6% men, aged 64 years, diabetes duration ≈10 years, BMI 29 kg/m², HbA1c 7.7–7.8% (61–62 mmol/mol)matched cohorts
- Participants
- 107 vs 107
- Exposure
- Injectable vs oral semaglutide
- Injectablen = 107
- Oraln = 107reference
- Outcome
- Change in HbA1c
- Follow-up
- Up to 18 months
Methodological detailspropensity-score matched, matched cohorts, Up to 18 months' follow-up
- Propensity-score matched
- Matched cohorts
- Up to 18 months' follow-up
Main finding
As reported in the abstract
Change in HbA1c similar between groups
−0.9% / −10 mmol/mol
Observational data: associations, not effects.
Further findings
Average, kg
| Outcome | Injectable | Oral |
|---|---|---|
| Change in body weight · up to 18 months | −3.7 | −3.3 |
HbA1c <6.5% (48 mmol/mol)
- Proportion reaching HbA1c <6.5% similar between groups
Change in body weight · up to 18 months
- Average change in body weight similar in the two groups
Weight loss ≥5%
- More new users of injectable semaglutide lost ≥5% body weight
Dose exposure
- Proportions of low, intermediate and high doses similar with oral and injectable
Drug persistence
- Persistence longer with injectable than oral semaglutide
Original publication
Oral or injectable semaglutide for the management of type 2 diabetes in routine care: A multicentre observational study comparing matched cohorts. Diabetes Obes Metab. Published 13 March 2024. doi:10.
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