Impact of Type 2 Diabetes and Glycated Hemoglobin Levels Within the Recommended Target Range on Mortality in Older Adults With Cognitive Impairment Receiving Care at a Memory Clinic: NCGG-STORIES
Authors' conclusion
HbA1c levels above and below the target range were associated with a higher risk of mortality, whereas patients with HbA1c levels within the target range did not exhibit a higher risk of mortality than individuals without type 2 diabetes. These results provide empirical support for the current target ranges among older adults with cognitive impairment.
Study context
- Population
- Older adults (≥65 years) with cognitive impairment visiting a memory clinic; 468 with T2D grouped by HbA1c, cognitive function, ADL ability and high-hypoglycaemia-risk medications468 with T2D
- Exposure
- T2D with HbA1c within, above or below the JDS/JGS target range vs no T2D
- Without T2Dn = 1,528reference
- Outcome
- Mortality
- Follow-up
- Median 3.8 years
Methodological detailsmemory clinic, Cox proportional hazards models
- Memory clinic
- Cox proportional hazards models
Main finding
As reported in the abstract
Death
Each group vs without T2DHazard ratio (95% CI)
Above target
1.70(1.08–2.69)
Below target
2.15(1.33–3.48)
Within target
1.02(0.77–1.36)
- Patients who died
- 353 (17.7%)
Observational data: associations, not effects.
Original publication
Impact of Type 2 Diabetes and Glycated Hemoglobin Levels Within the Recommended Target Range on Mortality in Older Adults With Cognitive Impairment Receiving Care at a Memory Clinic: NCGG-STORIES. Diabetes Care. Published 12 March 2024. doi:10.
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