Lipids & metabolic liver disease
Oral glucose absorption is enhanced in early metabolic dysfunction-associated steatotic liver disease
Authors' conclusion
Oral glucose absorption is augmented in individuals with MASLD without fibrosis, apparently unrelated to accelerated gastric emptying.
Study context
- Population
- Individuals with early-stage MASLD without fibrosis and matched healthy controls; separate cohort for gastric emptying
- Comparison
- Early-stage MASLD vs matched control individuals
- Outcome
- Kinetics of oral glucose absorption (rate of appearance of oral ingested glucose, RaO) during a 75 g OGTT
Methodological detailsmatched controls, stable isotopes, separate cohort for gastric emptying
- Matched controls
- Stable isotopes
- Separate cohort for gastric emptying
Main finding
As reported in the abstract
Difference
+318±142 µmol/kg
P = 0.031
RaO normalised to body weight at 1 h post-OGTT; 34% higher
Difference
+6.4±1.8 g
P = 0.001
total glucose absorption; 52% increase
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Association of 1 h RaO with prevalent MASLD (per 1-SD increase) · independent of potential confounders | 4.99 (1.44–31.57) | P = 0.036 | |
| 0.050.21520Odds ratio (log scale) |
Glucose clearance and endogenous glucose production
- MASLD: reduced glucose clearance relative to plasma insulin but preserved post-load suppression of endogenous glucose production (peripheral rather than hepatic insulin resistance)
Gastric emptying rate and hepatic steatosis risk
- Gastric emptying rate was not associated with hepatic steatosis risk
Original publication
Oral glucose absorption is enhanced in early metabolic dysfunction-associated steatotic liver disease. Diabetologia. Published 21 April 2026. doi:10.
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