Optimal dietary patterns for prevention of chronic disease
An erratum to this article was published (Nat Med, Jun 2024 ↗)
Authors' conclusion
Our results suggest that dietary patterns associated with markers of hyperinsulinemia and inflammation and diabetes development may inform on future dietary guidelines for chronic disease prevention.
Study context
- Population
- US healthcare professionals from three cohorts
- Participants
- 205,852 professionals3 US cohorts
- Exposure
- Higher vs lower adherence to two mechanism-based diets and six diets based on dietary recommendations
- Outcome
- Major chronic disease: composite of incident major CVD, T2D and cancer
- Follow-up
- Up to 32 years
Methodological detailsthree US cohorts, follow-up up to 32 years
- Three US cohorts
- Follow-up up to 32 years
Main finding
As reported in the abstract
Major chronic disease:
- Major CVD
- T2D
- Cancer
Hazard ratio (95% CI)
Low insulinemicvs 10th percentile
0.58(0.57–0.60)
Low inflammatoryvs 10th percentile
0.61(0.60–0.63)
Diabetes risk-reducingvs 10th percentile
0.70(0.69–0.72)
- HR range across healthy dietary patterns, 90th vs 10th percentile
- 0.58-0.80
Observational data: associations, not effects.
Further findings
Subgroups by gender and ethnicity
- Similar findings across gender and diverse ethnic groups
Original publication
Optimal dietary patterns for prevention of chronic disease. Nat Med. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →