Opportunistic Screening With Computed Tomography (CT): Comparison of Phantomless Bone Mineral Density (BMD) Calibration Methods
Authors' conclusion
In conclusion, phantomless BMD calibration performs well if precalibrated with a reference dataset.
Study context
- Population
- CT scans for opportunistic osteoporosis screening: DS1, 350 females with a highly standardized CT protocol; DS2, 114 patients (38 female) from clinical routine with a wide range of CT acquisition and reconstruction parametersDS1 350
- Comparison
- Four existing phantomless BMD calibration methods plus a fifth method based on average calibration parameters vs simultaneous calibration
- Outcome
- ΔBMD vs simultaneous calibration
Methodological detailsphantomless BMD calibration, comparison against simultaneous calibration as gold standard, Precalibration: 60 scans from DS1 and 57 from DS2 randomly selected, Best combination of internal reference materials selected per method: air and blood, or subcutaneous adipose tissue, blood and cortical bone
- Phantomless BMD calibration
- Comparison against simultaneous calibration as gold standard
- Precalibration: 60 scans from DS1 and 57 from DS2 randomly selected
- Best combination of internal reference materials selected per method: air and blood, or subcutaneous adipose tissue, blood and cortical bone
Main finding
As reported in the abstract
| Group | Value | DS2 ΔBMD (mean ± SD) |
|---|---|---|
| Phantomless method without precalibration | mean 12.6 (SD 13.2) mg/cm³ | 0.5 ± 8.8 mg/cm³ |
Phantomless method without precalibration
Valuemean 12.6 (SD 13.2) mg/cm³
DS2 ΔBMD (mean ± SD)0.5 ± 8.8 mg/cm³
- Precalibrated phantomless methods, DS1: ΔBMD (mean ± SD) range
- 0.1 ± 2.7 mg/cm³ to 2.4 ± 3.5 mg/cm³
Original publication
Opportunistic Screening With CT: Comparison of Phantomless BMD Calibration Methods. J Bone Miner Res. Published 1 October 2023. doi:10.
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