Buds of new bone formation within the Femoral Head of Hip Fracture Patients Coincide with Zones of Low Osteocyte Sclerostin
Authors' conclusion
These results demonstrate modeling-based bone formation in femoral trabeculae from patients with hip fracture as a potential therapeutic target to enhance bone structure.
Study context
- Population
- Patients with hip fracture; trabecular cores from different parts of the femoral head
- Comparison
- Femoral head zones: superomedial vs superolateral and inferomedial
- Outcome
- FMiS density (N.FMiS/T.Ar)
Methodological detailsTrabecular bone structure measured with high-resolution imaging
- Trabecular bone structure measured with high-resolution imaging
Main finding
As reported in the abstract
- Fewer sclerostin expressing osteocytes close to or within FMiS
- Superomedial vs Superolateral: P < 0.05
- Superomedial vs Inferomedial: P < 0.001
Further findings
Correlation of FMiS density with trabecular structure
- BV/TV, r
- 0.65, p < 0.0001
- BS/TV, r
- 0.47, p < 0.01
- Tb.Th, r
- 0.55, p < 0.001
- Tb.N, r
- 0.47, p < 0.01
- Conn.D, r
- 0.40, p < 0.05
- Tb.Sp, r
- −0.56, p < 0.001
Original publication
Buds of new bone formation within the Femoral Head of Hip Fracture Patients Coincide with Zones of Low Osteocyte Sclerostin. J Bone Miner Res. Published 29 September 2023. doi:10.
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