One-hour glucose is an earlier marker of dysglycemia than two-hour glucose
Authors' conclusion
1 h-PG ≥ 155 mg/dl is an earlier marker of elevated risk for PreDM and T2D than 2 h-PG ≥ 140 mg/dl.
Study context
- Population
- Southwest Native Americans followed longitudinally for 6–10 years with at least 3 OGTTs
- Participants
- 201 participants
- Comparison
- Timing of 1 h-PG vs 2 h-PG threshold crossing
- Primary endpoint
- Timing of crossing of 1 h-PG thresholds vs current 2 h-PG thresholds for PreDM and T2D
Methodological detailsat least 3 OGTTs per participant
- At least 3 OGTTs per participant
Primary result
As reported in the abstract
- PreDM: time by which 1 h-PG preceded 2 h-PG, median [IQR]
- 1.7 [−0.25, 4.59] y
- PreDM: time by which 1 h-PG preceded 2 h-PG, mean ± SEM
- 5.3 ± 1.9 y
- T2D subset: 1 h-PG reached 209 mg/dl before 2 h-PG reached 200 mg/dl
- 25/33, 75%
- T2D: time by which 1 h-PG preceded 2 h-PG, median [IQR]
- 1.0 [−0.56, 2.02] y
- T2D: time by which 1 h-PG preceded 2 h-PG, mean ± SEM
- 1.6 ± 0.8 y
Further findings
- Subset who first developed T2D
- 33
- 1 h-PG reached 209 mg/dl earlier than 2 h-PG reached 200 mg/dl
- 25/33, 75%
- Lead time, median [IQR]
- 1.0 [−0.56, 2.02] y
- Lead time, mean ± SEM
- 1.6 ± 0.8 y
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
One-hour glucose is an earlier marker of dysglycemia than two-hour glucose. Diabetes Res Clin Pract. Published 21 July 2023. doi:10.
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