Obesity Is Associated With Hyperandrogenemia in a Nationally Representative Sample of US Girls Aged 6 to 18 Years
Authors' conclusion
In a nationally representative sample of US girls, obesity is associated with elevated free testosterone, suggesting an important relationship between obesity and peripubertal hyperandrogenemia.
Study context
- Population
- US girls aged 6–18 years, National Health and Nutrition Examination Survey 2013–2016
- Participants
- 1,299 participants
- Exposure
- Girls with obesity vs healthy-weight girls
- Outcome
- Mean free testosterone concentration (calculated from total testosterone and SHBG)
Methodological detailsnationally representative sample, NHANES 2013-2016
- Nationally representative sample
- NHANES 2013-2016
Main finding
As reported in the abstract
Mean free testosterone by age group
| Group | Value | Age group |
|---|---|---|
| Healthy weight | mean 0.33 (95% CI 0.28–0.38) pg/mL | 6 to 9 years |
| Obesity | mean 0.86 (95% CI 0.67–1.05) pg/mL | 6 to 9 years |
| Healthy weight | mean 2.29 (95% CI 2.05–2.53) pg/mL | 10 to 14 years |
| Obesity | mean 4.10 (95% CI 3.60–4.60) pg/mL | 10 to 14 years |
| Healthy weight | mean 3.33 (95% CI 2.96–3.70) pg/mL | 15 to 18 years |
| Obesity | mean 5.64 (95% CI 4.93–6.36) pg/mL | 15 to 18 years |
Value
Healthy weightmean 0.33 (95% CI 0.28–0.38) pg/mL
Obesitymean 0.86 (95% CI 0.67–1.05) pg/mL
Healthy weightmean 2.29 (95% CI 2.05–2.53) pg/mL
Obesitymean 4.10 (95% CI 3.60–4.60) pg/mL
Healthy weightmean 3.33 (95% CI 2.96–3.70) pg/mL
Obesitymean 5.64 (95% CI 4.93–6.36) pg/mL
Age group
Healthy weight6 to 9 years
Obesity6 to 9 years
Healthy weight10 to 14 years
Obesity10 to 14 years
Healthy weight15 to 18 years
Obesity15 to 18 years
Observational data: associations, not effects.
Further findings
Multiple regression model for free testosterone
- Variance in free testosterone explained (R2)
- 0.42
- Weight and age categories independent predictors of free testosterone
- P < 0.0001 for each
Original publication
Obesity Is Associated With Hyperandrogenemia in a Nationally Representative Sample of US Girls Aged 6 to 18 Years. J Clin Endocrinol Metab. Published 23 September 2024. doi:10.
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