Obesity and overweight are linked to increased sodium‐glucose cotransporter 1 and glucose transporter 5 levels in duodenum
Authors' conclusion
Individuals with overweight and obesity display enhanced duodenal SGLT-1 and GLUT-5 abundance, which correlates with increased postprandial glucose concentrations, insulin resistance, and hyperinsulinemia.
Study context
- Population
- Individuals without diabetes with duodenal mucosa biopsies, categorized by BMI
- Participants
- 52 individuals
- Exposure
- Overweight and obesity vs lean
- Outcome
- Duodenal protein levels of SGLT-1, GLUT-2 and GLUT-5
Main finding
As reported in the abstract
Duodenal glucose carrier protein levels
- Progressively increased duodenal SGLT-1 and GLUT-5 protein levels in overweight and obesity vs lean
- No differences in duodenal GLUT-2 abundance among the three groups
Observational data: associations, not effects.
Further findings
Correlations of SGLT-1 and GLUT-5 levels (univariate analysis)
- SGLT-1 and GLUT-5 positively correlated with BMI, waist circumference, 1-h post-load glucose, fasting and post-load insulin, and insulin secretion and resistance
- Positive relationship between intestinal GLUT-5 levels and serum uric acid
Original publication
Obesity and overweight are linked to increased sodium‐glucose cotransporter 1 and glucose transporter 5 levels in duodenum. Obesity (Silver Spring). Published 6 February 2023. doi:10.
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