NT-proBNP levels in patients with primary hyperaldosteronism and autonomous cortisol cosecretion
Authors' conclusion
In patients with PA, concomitant ACS is associated with a worse cardiac profile and only partial recovery even years after initiation of targeted PA therapy.
Study context
- Population
- Patients with PA undergoing 1 mg dexamethasone suppression test and echocardiography, 2 centers of the German Conn's Registry192 with follow-up
- Participants
- 367 patients
- Exposure
- PA with ACS vs PA without ACS
- Outcome
- NT-proBNP
- Follow-up
- Baseline
Methodological details2 centers, German Conn's Registry
- 2 centers
- German Conn's Registry
Main finding
As reported in the abstract
P = 0.02
Observational data: associations, not effects.
Further findings
Correlation of NT-proBNP with cortisol after dexamethasone suppression test (DST) · baseline
- Significant positive correlation
- r = 0.141, P = .011
NT-proBNP after PA therapy · follow-up
- NT-proBNP decreased but remained significantly higher with ACS than without ACS
Echocardiography at follow-up (left ventricle end-diastolic dimension (LVEDD), left atrial diameter (LAD), left ventricular mass index (LVMI)) · follow-up up to 3.8 years
- LVEDD decreased significantly only without ACS
- LAD decreased significantly without ACS and in females with ACS, not in males
- LVMI improved significantly in females without ACS; unchanged in females with ACS and in males
Original publication
NT-proBNP levels in patients with primary hyperaldosteronism and autonomous cortisol cosecretion. Eur J Endocrinol. Published 29 September 2024. doi:10.
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