Prevalence of adrenal rest tumors and course of gonadal dysfunction in a clinical sample of men with congenital adrenal hyperplasia: a longitudinal analysis over 10 years
Authors' conclusion
T levels below the normal range are frequent in men with 21OHD, regardless of TART, but change little over time. Besides adrenal androgen control gonadal axis suppression from supraphysiological glucocorticoid dosages needs to be considered. While our results do not endorse regular screening for alterations in TART status among adults, Sertoli cell function should be monitored in men with large TART.
Study context
- Population
- Men with classic 21-hydroxylase deficiency (21OHD); median observation period 12 years
- Participants
- 27 men
- Exposure
- Men with TART vs without TART
- TARTn = 11
- Outcome
- Long-term evolution of gonadal function (T, 11-oxygenated androgens, gonadotropins, inhibin B)
- Follow-up
- Median observation period 12 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
n.s.
Observational data: associations, not effects.
Further findings
T adjusted for BMI, SHBG and age
T adjusted for BMI, SHBG and age
- Men with TART exhibited higher T than those without
T during observation period · start to end of observation
- TART: T rose from 10.1 ± 1.1 to 17.3 ± 1.9 nmol/L
- No TART: T rose from 10.3 ± 1.0 to 12.8 ± 1.9 nmol/L
- Accompanied by rising LH
Hydrocortisone equivalent dosage during observation period · start to end of observation
- TART: from 38.1 ± 3.2 to 35.1 ± 1.8 mg/d
- No TART: from 28.8 ± 2.7 to 28.1 ± 1.6 mg/d
- No correlation with any markers of adrenal androgen control
Inhibin B and TART status over time
- Inhibin B declined in men with large TART over time; TART status remained stable
Original publication
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