Effect of mild cortisol cosecretion on body composition and metabolic parameters in patients with primary hyperaldosteronism
Authors' conclusion
MACE in PA patients does not translate into body composition changes on CT-imaging. Therefore, early detection of concurrent CCS in PA is currently only attainable through biochemical tests. Further investigation of the long-term clinical adverse effects of MACE in PA is necessary.
Study context
- Population
- Patients with PA; body composition at third lumbar region on non-contrast-enhanced computed tomography (CT)matched by age and sex
- Participants
- 47 vs 47
- Exposure
- PA with cortisol cosecretion vs PA without cortisol cosecretion (CCS)
- CCSn = 47
- non-CCSn = 47reference
- Outcome
- Total, visceral and subcutaneous fat volumes on CT
Methodological detailsmatched by age and sex
- Matched by age and sex
Main finding
As reported in the abstract
- No difference in total, visceral and subcutaneous fat volumes between CCS and non-CCS
- CCS vs non-CCS: P = 0.7
- CCS vs non-CCS: .6
- CCS vs non-CCS: .8
Observational data: associations, not effects.
Further findings
Cortisol after 1-mg DST
Total serum cholesterol vs serum cortisol after 1-mg dexamethasone suppression test (DST)
- Significant correlation on multivariable regression
- P = 0.026
Body composition by visible lesion on CT and PA-lateralization via AVS
- No significant differences in body composition
Original publication
Effect of mild cortisol cosecretion on body composition and metabolic parameters in patients with primary hyperaldosteronism. Clin Endocrinol (Oxf). Published 1 January 2024. doi:10.
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