Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study
Authors' conclusion
DST cortisol is an independent risk factor for lower eGFR in patients with adrenal adenomas. Patients with both MACS and NFA demonstrate an increase in eGFR post adrenalectomy, especially younger patients with lower eGFR pre adrenalectomy.
Study context
- Population
- Patients with NFA or mild autonomous cortisol secretion (MACS), single centre, 1999 to 2020
- Participants
- 972 patients
- Exposure
- MACS vs NFA
- MACSn = 429
- NFAn = 543reference
- Outcome
- eGFR at diagnosis of MACS or NFA, and post-adrenalectomy delta eGFR
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
eGFR at diagnosis
P < 0.001
Observational data: associations, not effects.
Further findings
eGFR after adrenalectomy · from 18 months up to 3.5 years
- Estimated glomerular filtration rate (eGFR) after adrenalectomy: 204 patients treated with adrenalectomy
eGFR after adrenalectomy · from 18 months up to 3.5 years
- Post-adrenalectomy eGFR improved in both groups
- Factors associated with increased eGFR: younger age, lower pre-adrenalectomy eGFR, longer follow-up
Original publication
Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study. J Clin Endocrinol Metab. Published 29 December 2023. doi:10.
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