NT-proBNP and cardiovascular event risk in individuals with prediabetes undergoing cardiovascular evaluation
Authors' conclusion
NT-proBNP independently predicts increased long-term MACE and mortality risks in prediabetic subjects, and may help identify those for whom more aggressive global preventive efforts are indicated.
Study context
- Population
- Stable subjects with prediabetes undergoing cardiovascular risk evaluation
- Participants
- 3,235 subjects
- Exposure
- NT-proBNP Q4 vs Q1
- Outcome
- MACE (death, MI, stroke) and all-cause mortality
- Follow-up
- 3-year MACE; 5-year all-cause mortality
Main finding
As reported in the abstract
3-year MACE · 3 years
Q4 vs Q1Estimate (95% CI)P value
Cox proportional hazard models
HR 6.04(4.17–8.76)
P < 0.001Adjusted for traditional CV risk factors, glycemic indices, CVD, LVEF, medication use
aHR 2.65(1.16–6.05)
P < 0.05Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| 5-year all-cause mortality · 5 yearsQ4vs Q1 | HR 8.64 (95% CI 5.78–12.9) | P < 0.001 | |
| 5-year all-cause mortality · 5 yearsQ4vs Q1 | aHR 3.45 (95% CI 1.42–8.39) | P < 0.01 | |
| 0.050.21520Ratio (log scale) |
- 5-year all-cause mortality: adjusted for traditional CV risk factors, glycemic indices, cardiovascular disease (CVD), left ventricular ejection fraction (LVEF), medication use
Prognostic value (C-statistic, NRI, IDI)
- NT-proBNP significantly improved prognostic value for 3-year major adverse cardiac events (MACE) and 5-year death when added to models
Original publication
NT-proBNP and cardiovascular event risk in individuals with prediabetes undergoing cardiovascular evaluation. Diabetes Res Clin Pract. Published 27 September 2023. doi:10.
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