Normalization of hyponatremia in hospitalized patients decreases osteoclast activity
Main finding · Serum CTXResult — go to the resultΒ-coefficient (decrease in CTX) −.18 95% CI −0.30 to −0.08Authors' conclusion
In hospitalized patients with hyponatremia, sodium normalization is associated with attenuated osteoclast activity. Correction of even mild hyponatremia could thus be beneficial for counteracting bone loss.
Study context
- Population
- Hospitalized patients with serum sodium <135 mmol/L, University Hospital of Basel, Switzerland, 03/2020–02/2025; excluded premenopausal status, steroid therapy, hypogonadism, fractures, hyperparathyroidism, anti-osteoporotic treatments; 65.8% male, mean age 68.6 yearscompleted the study
- Participants
- 41 patients
- Exposure
- Normonatremia vs persistent hyponatremia at day 10
- Normonatremian = 22
- Persistent hyponatremian = 19reference
- Outcome
- Osteoclast activity: bone resorption marker serum CTX
- Follow-up
- 10 (±3) days
Methodological detailssingle-centre
- Single-centre
Main finding
Serum CTX · day 10
Β-coefficient (decrease in CTX)
−.18
95% CI −0.30 to −0.08
P = 0.002
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Serum CTX at baseline · similar
P = 0.35
- P1NP (bone formation) · baseline and day 10
- P > 0.05
P1NP (bone formation) · baseline and day 10
- No differences between persistent and normalized sodium
Sodium at baseline
- Median (IQR) sodium
- 130 mmol/L (127-132)
- Mild hyponatremia
- 60%
Original publication
Normalization of hyponatremia in hospitalized patients decreases osteoclast activity. Eur J Endocrinol. Published 21 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →