Normal Reference Range for Glucose Rates of Change in Nondiabetic Individuals Using Continuous Glucose Monitoring
Authors' conclusion
Over 15 min, the median time with RoC exceeding ±2 mg/dL/min was minimal (1.4% rising, 1.0% falling). RoC was slower when measured over longer intervals, faster when rising than falling, faster during daytime hours, and exhibited modest differences across age groups.
Study context
- Population
- Healthy, nondiabetic individuals wearing continuous glucose monitoring (CGM) (Dexcom G6, up to 10 days)
- Participants
- 153 participants
- Outcome
- Percentage of time exceeding various glucose rate-of-change (RoC) thresholds over 5-, 15-, 30- and 60-min intervals
Main finding
As reported in the abstract
Median time with RoC exceeding ±2 mg/dL/min over 15 min
Median time with rates of change (RoC) >+2 mg/dL/min (rising), over 15 min
1.4%
Median time with RoC <−2 mg/dL/min (falling), over 15 min
1.0%
Further findings
RoC by interval, direction, time of day and age
- RoC was slower when measured over longer intervals, faster when rising than falling, faster during daytime hours, and showed modest differences across age groups
Original publication
Normal Reference Range for Glucose Rates of Change in Nondiabetic Individuals Using Continuous Glucose Monitoring. Diabetes Technol Ther. Published 20 November 2025. doi:10.
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