Diabetes technology

Noninvasive Real-Time Glucose Monitoring Is in the Near Future

Diabetes Technol TherPublished Diagnostic accuracy study

Authors' conclusion

Our results show promise as potentially the first noninvasive technology.

Study context

Population
Subjects with T2D, T1D, nondiabetic pregnant subjects and nondiabetic subjectsSubjects with T2D 6 · T1D 28 · nondiabetic pregnant subjects 10 · nondiabetic subjects 31
Participants
75 subjects
Comparison
Noninvasive GWave device vs capillary blood glucose
Outcome
Accuracy vs reference capillary blood glucose (Clarke Error Grid; mean absolute relative difference)

Performance

As reported in the abstract

Values in Zone A of the Clarke Error Grid

97%

Values in Zone B of the Clarke Error Grid

3%

Mean absolute relative difference from reference blood glucose

6.7%

Further findings

Reproducibility between two independent Gen III GWave devices

Reproducibility between sensors, R2
0.95
Values within Zone A
100%

Accuracy during insulin-induced hypoglycaemia

Gen III sensor tightly followed capillary glucose down to 42 mg/dL (2.3 mmol/L); Continuous glucose monitoring (CGM) measurements from two different CGM only converged with GWave and capillary readings after 90 min of decreasing glucose

Original publication

Noninvasive Real-Time Glucose Monitoring Is in the Near Future. Diabetes Technol Ther. Published 17 May 2024. doi:10.1089/dia.2024.0009

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