Non-suppression of renin by renal cysts in a subset of patients with primary aldosteronism—a prospective observational single center study
Authors' conclusion
Renal cysts are found in the majority of patients with primary aldosteronism, and they may interfere with diagnostics, especially in patients aged 50 years or less. In patients with non-suppressed renin due to renal cysts, aldosterone-to-renin ratio below the diagnostic threshold does not always exclude the diagnosis of primary aldosteronism.
Study context
- Population
- Patients with confirmed PA undergoing AVS, recruited October 7, 2020 to December 30, 2021consecutive
- Participants
- 114 patients
- Exposure
- Renal cysts vs no renal cysts
- High-normal reninn = 11
- Low to low-normal reninn = 102reference
- Outcome
- Association between renal cysts (contrast-enhanced CT) and non-suppressed plasma renin
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Prevalence of renal cysts
P = 0.027
- Renal cysts in all patients
- 58.2%
Observational data: associations, not effects.
Further findings
Renal cysts in patients ≤50 years with high-normal renin
- All patients ≤50 years in the high-normal renin group had renal cysts
Correlations of renin measurements
- Renin concentration, right vs left renal vein
- r = .984
- Renin concentration vs renin activity, inferior vena cava
- r = .817
Original publication
Non-suppression of renin by renal cysts in a subset of patients with primary aldosteronism—a prospective observational single center study. Eur J Endocrinol. Published 11 July 2023. doi:10.
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