Substantial changes in inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion
Authors' conclusion
There was a systemic rise in inflammatory biomarkers in patients with ACS and CS, not correlated to the degree of hypercortisolism. These biomarkers were not normalized following biochemical cure.
Study context
- Population
- Patients with autonomous cortisol secretion (ACS) or overt Cushing syndrome (CS) and healthy subjects; serum analysed for 92 inflammatory biomarkers by proximity extension assay (OLINK)
- Participants
- 63 / 2 / 8 / 120
- Exposure
- ACS and CS vs healthy controls
- ACSn = 63
- Adrenal CSn = 2
- Pituitary CSn = 8
- Healthyn = 120reference
- Outcome
- Inflammatory biomarker levels, ACS and CS combined vs healthy controls
Methodological detailsprospectively included patients
- Prospectively included patients
Main finding
As reported in the abstract
Biomarkers with significant differences vs healthy controls
49 of 92
Increased
46
Decreased
3
Observational data: associations, not effects.
Further findings
ACS vs overt CS
- No differences in biomarker levels between ACS and overt CS
Correlation with degree of hypercortisolism
- None of the biomarkers correlated with the degree of hypercortisolism
Postoperative biomarkers · median 24 months (range 6-40) after surgery and biochemical curation
- Patients with postoperative samples
- 17
- No significant normalization of the biomarkers postoperatively
Original publication
Substantial changes in inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion. Eur J Endocrinol. Published 8 July 2023. doi:10.
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