Effect of Obesity on Clinical Characteristics of Primary Aldosteronism Patients at Diagnosis and Postsurgical Response
Authors' conclusion
Obesity in PA patients involves a worse cardiometabolic profile, and need for more antihypertensive drugs but similar PAC and renin levels, and rates of adrenal lesions and lateral disease than patients without obesity. However, obesity implicates a lower rate of hypertension cure after adrenalectomy.
Study context
- Population
- Patients with primary aldosteronism (PA) in the Spanish PA Registry (SPAIN-ALDO), 20 tertiary centers, 2018–2022; median age 55 years (range 47.3–65.2), 240 (58.4%) male
- Participants
- 415 patients
- Exposure
- PA with obesity vs PA without obesity
- Obesityn = 189
- Outcome
- Clinical characteristics of PA by obesity
- Follow-up
- Diagnosis
Methodological detailsmulticentre, 20 tertiary centers
- Multicentre
- 20 tertiary centers
Main finding
As reported in the abstract
- Obesity: higher rates of DM, CKD, obstructive apnea syndrome, left ventricular hypertrophy, prior cardiovascular events, higher mean systolic BP and more antihypertensive drugs vs no obesity
- Obesity: higher serum glucose, HbA1c, creatinine, uric acid and TG, and lower HDL-C
- PAC and renin similar between patients with and without obesity
- BMI not correlated with PAC nor renin
- Rates of adrenal lesions on imaging and of unilateral disease (AVS or I-6β-iodomethyl-19-norcholesterol scintigraphy) similar between groups
Observational data: associations, not effects.
Original publication
Effect of Obesity on Clinical Characteristics of Primary Aldosteronism Patients at Diagnosis and Postsurgical Response. J Clin Endocrinol Metab. Published 10 July 2023. doi:10.
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