Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes
Authors' conclusion
We demonstrate the feasibility of using 11C-HED-PET for non-invasive assessment of pancreatic sympathetic innervation in humans. These findings warrant further prospective evaluation, especially in individuals with theoretical defects in pancreatic sympathetic innervation, such as those with type 1 diabetes.
Study context
- Population
- Individuals who had previously undergone 11C-HED-PET/CT because of pheochromocytoma or paraganglioma (or suspicion thereof)
- Participants
- 25 vs 64
- Exposure
- T2D vs no diabetes
- T2Dn = 25
- No diabetesn = 64reference
- Outcome
- Feasibility of 11C-HED positron emission tomography (PET) for quantitative imaging of pancreatic sympathetic innervation
Main finding
As reported in the abstract
- Pancreatic 11C-HED uptake generally high, with marked individual variation
- T2D vs No diabetes: P < 0.001
- T2D vs No diabetes: P = 0.0049
- T2D vs No diabetes: P = 0.0142
- T2D vs No diabetes: P = 0.15
- T2D vs No diabetes: P = 0.73
- T2D vs No diabetes: P = 0.30
Observational data: associations, not effects.
Original publication
Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes. Diabetologia. Published 7 November 2023. doi:10.
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