Type 2 & other diabetes

Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis

Diabetes Obes MetabPublished Age-period-cohort analysis of Global Burden of Disease Study 2019 data

Authors' conclusion

After a lengthy period of multi-initiative diabetes management, the high-middle SDI region exhibited improvement. However, unresolved issues and improvement gaps were still remarkable. Future efforts to reduce the burden of CKD attributable to T2D in the population should prioritize addressing the unfavourable patterns identified.

Study context

Population
Global population and five sociodemographic index (SDI) regions, chronic kidney disease (CKD) attributable to T2D, 1990–2019
Outcome
Temporal trends of CKD attributable to T2D: DALYs, mortality, prevalence and incidence (net drifts, local drifts, longitudinal age curves, period and cohort RRs)
Follow-up
1990 to 2019
Methodological detailsage-period-cohort modelling, global and five SDI regions
  • Age-period-cohort modelling
  • Global and five SDI regions

Main finding

As reported in the abstract

Burden of CKD attributable to T2D
  • Global burden of CKD attributable to T2D showed increasing trends in general
  • Burden highest in the middle SDI region and lowest in the low SDI region
  • Age effects increased with age, peaking at ages 75-79 for incidence and 80-84 years for prevalence
  • Period relative risks (RRs) increased; most remarkable in high SDI for disability-adjusted life years (DALYs) and mortality, most notable in middle SDI for incidence
  • Cohort RRs showed unfavourable trends in incidence and prevalence among recent cohorts

Observational data: associations, not effects.

Original publication

Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis. Diabetes Obes Metab. Published 7 November 2023. doi:10.1111/dom.15349

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