No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women
Authors' conclusion
We conclude that the present analysis provides no support for the suggestion that NSAIDs interfere with the efficacy of potent bisphosphonates in terms of their effects on bone density or fracture.
Study context
- Population
- Osteopenic postmenopausal women in a 6-year RCT of zoledronate
- Participants
- 2,000 women
- Comparison
- Zoledronate effects on BMD and fracture by NSAID use vs non-use
Methodological details6-year
- 6-year
Primary result
As reported in the abstract
- Zoledronate effects on BMD almost identical with or without baseline NSAID use; significant in both subgroups at all BMD sites
- p < 0.0001
- Fracture risk reduction with zoledronate
- p < 0.0001
Further findings
NSAID use prevalence
- NSAID use at baseline
- 38%
- Anytime NSAID use
- 65%
Original publication
No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women. J Bone Miner Res. Published 2 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →