No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes
Authors' conclusion
Six months of treatment with 1.2 mg/day of liraglutide had no effect on the kinetics of HDL apoAI in patients with T2D. The lack of decrease in triglyceride content in HDL related to an only moderate decrease in triglyceridemia, probably greatly explains these results. Insufficient improvement of insulin sensitivity and adiponectinemia may also be implied.
Study context
- Population
- Patients with T2D
- Participants
- 10 patients
- Comparison
- After vs before 6 months of liraglutide 1.2 mg/day
- Outcome
- HDL apoAI kinetics (fractional catabolic rate, production rate)
- Follow-up
- 6 months
Methodological detailsin vivo kinetic study, bolus of l-[1-13C]leucine followed by 16-hour constant infusion
- In vivo kinetic study
- Bolus of l-[1-13C]leucine followed by 16-hour constant infusion
Main finding
As reported in the abstract
HDL apoAI kinetics
- Liraglutide modified neither high density lipoprotein (HDL) apolipoprotein AI (apoAI) fractional catabolic rate, nor production rate, nor plasma concentration
- Between After liraglutide and Before liraglutide: P = 0.375
- Between After liraglutide and Before liraglutide: P = 0.375
- Between After liraglutide and Before liraglutide: P = 0.386
Further findings
| Outcome | P value |
|---|---|
| BMI, HbA1c, HOMA-IR, fasting TG, TG during kinetics · 6 monthsBetween After liraglutide and Before liraglutide · BMI | P = 0.012 |
| BMI, HbA1c, HOMA-IR, fasting TG, TG during kinetics · 6 monthsBetween After liraglutide and Before liraglutide · HbA1c | P = 0.003 |
| BMI, HbA1c, HOMA-IR, fasting TG, TG during kinetics · 6 monthsBetween After liraglutide and Before liraglutide · HOMA-IR | P = 0.003 |
| BMI, HbA1c, HOMA-IR, fasting TG, TG during kinetics · 6 monthsBetween After liraglutide and Before liraglutide · Fasting TG | P < 0.001 |
| BMI, HbA1c, HOMA-IR, fasting TG, TG during kinetics · 6 monthsBetween After liraglutide and Before liraglutide · TG during kinetics | P = 0.053 |
| HDL-C, adiponectin, TG content in HDL · 6 monthsBetween After liraglutide and Before liraglutide · HDL-C | P = 1 |
| HDL-C, adiponectin, TG content in HDL · 6 monthsBetween After liraglutide and Before liraglutide · Adiponectin | P = 0.160 |
| HDL-C, adiponectin, TG content in HDL · 6 monthsBetween After liraglutide and Before liraglutide · TG content in HDL | P = 0.386 |
BMI, HbA1c, HOMA-IR, fasting TG, TG during kinetics · 6 months
- Liraglutide reduced BMI, HbA1c, HOMA-IR, fasting TG and TG during kinetics
HDL-C, adiponectin, TG content in HDL · 6 months
- Plasma HDL-C, adiponectin and TG content in HDL unchanged
Original publication
No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes. Diabetes Metab. Published 21 April 2024. doi:10.
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