Glucose Color Index: Development and Validation of a Novel Measure of the Shape of Glycemic Variability
Authors' conclusion
We developed and validated the GCI, a novel CGM metric that captures the shape of glucose variability using the periodogram signal decomposition. Glucose Color Index was reliable within participants over a three-month period and associated with diabetes comorbidities. The GCI suggests a promising avenue toward the development of CGM metrics which more fully incorporate time series information.
Study context
- Population
- Adults with T2D wearing continuous glucose monitoring (CGM): 141 from the HYPNOS trial (development, test-retest); 398 older adults from the Atherosclerosis Risk in Communities (ARIC) study (comorbidity associations)141 HYPNOS
- Outcome
- GCI test-retest correlation
- Follow-up
- Two CGM wears, three months apart
Methodological detailssecondary analysis of CGM data from the HYPNOS trial, external validation in the ARIC study
- Secondary analysis of CGM data from the HYPNOS trial
- External validation in the ARIC study
Performance
As reported in the abstract
Glucose Color Index (GCI) test-retest correlation
R = .75
GCI test-retest correlation adjusted for standard CGM metrics
R = .55
Further findings
Association of GCI with diabetes comorbidities (ARIC)
- GCI significantly associated with impaired physical functioning, frailty/pre-frailty, CVD, CKD and dementia/mild cognitive impairment after adjustment for confounders
- P < 0.05
Original publication
Glucose Color Index: Development and Validation of a Novel Measure of the Shape of Glycemic Variability. J Diabetes Sci Technol. Published 20 April 2024. doi:10.
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