Neuropathic Pain With and Without Diabetic Peripheral Neuropathy in Type 1 Diabetes
Authors' conclusion
NP incidence in T1D was high and frequently occurred in the absence of clinical signs of neuropathy, as assessed with the MNSI. Pain remission was not explained by pain medication use. Effective clinical strategies for identification and management are needed.
Study context
- Population
- Participants with T1D in the Epidemiology of Diabetes Interventions and Complications (EDIC) study; at EDIC year 1 median age 36 years, diabetes duration 13 years, HbA1c 7.9%EDIC study
- Participants
- 1,324 participants
- Exposure
- Neuropathic pain (NP) with clinical signs of diabetic peripheral neuropathy (DPN) vs NP without clinical signs of DPN
- Outcome
- Incidence of first occurrence, annual prevalence, remission and risk factors for neuropathic pain (NP)
Methodological detailslong-term follow-up, annual Michigan Neuropathy Screening Instrument (MNSI) administration 1994-2020
- Long-term follow-up
- Annual MNSI administration 1994-2020
Main finding
As reported in the abstract
Cumulative incidence of NP · year 26 (median diabetes duration 39 years)
- Cumulative incidence of NP, regardless of concomitant clinical signs of DPN
- 57%
Observational data: associations, not effects.
Further findings
NP prevalence · 26 years
- NP prevalence — Overall NP prevalence, suggesting frequent remission
- 20%
Annualized remission rates
- Similar regardless of pain medication use
Risk factors for NP DPN-
- In addition to HbA1c, female sex was associated with NP DPN-
Original publication
Neuropathic Pain With and Without Diabetic Peripheral Neuropathy in Type 1 Diabetes. Diabetes Care. Published 1 February 2024. doi:10.
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