Nasopharyngeal carriage and antibiotic susceptibility of Streptococcus pneumoniae among diabetes patients in western Kenya
Main finding · S. pneumoniae carriageResult — go to the resultAdjusted odds ratio 6.2Authors' conclusion
Nasopharyngeal carriage of S. pneumoniae is higher in patients with diabetes, with significant resistance to common antibiotics, though macrolides remain effective.
Study context
- Population
- Patients attending Moi Teaching and Referral Hospital (MTRH) diabetes and eye clinics, western Kenya
- Participants
- 124 vs 121
- Exposure
- Patients with vs without diabetes
- Diabetesn = 124
- Non-diabetesn = 121reference
- Outcome
- Nasopharyngeal carriage of S. pneumoniae
Methodological detailssystematic random sampling
- Systematic random sampling
Main finding
S. pneumoniae carriage
Adjusted odds ratio
6.2
P = 0.012
By group
As reported in the abstract
- Overall carriage
- 7.4 % (95 % CI: 4.4, 11.4)
Observational data: associations, not effects.
Further findings
Overall S. pneumoniae carriage
- Overall carriage
- 7.4 % (95 % CI: 4.4, 11.4)
Antibiotic resistance of S. pneumoniae isolates
%
- Cotrimoxazole resistance (highest)
- 94.44
- Amoxicillin resistance
- 16.7
- Cefuroxime resistance
- 11.1
- No resistance to macrolides was observed
Other risk factors for carriage
- No association with age, sex, cooking fuel, presence of children under 5, or prior antibiotic use
- Among participants with diabetes, carriage only associated with insulin use
Original publication
Nasopharyngeal carriage and antibiotic susceptibility of Streptococcus pneumoniae among diabetes patients in western Kenya. Diabetes Res Clin Pract. Published 16 October 2024. doi:10.
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