Estimated glucose disposal rate, high sensitivity C-reactive protein and cardiometabolic multimorbidity in middle-aged and older Chinese adults: A nationwide prospective cohort study
Authors' conclusion
Low eGDR and high hsCRP were individually and jointly associated with increased risk of incident CMM. The findings highlighted the importance of joint evaluation of eGDR and hsCRP for primary prevention of CMM.
Study context
- Population
- Participants aged ≥45 years with estimated glucose disposal rate (eGDR) and high-sensitivity C-reactive protein (hsCRP) data and without cardiometabolic diseases at baseline, China Health and Retirement Longitudinal Study
- Participants
- 6,900 participants
- Exposure
- Low vs high eGDR and high vs low hsCRP, separately and jointly
- Outcome
- Incident cardiometabolic multimorbidity (CMM): coexistence of ≥2 cardiometabolic diseases (heart diseases, stroke, diabetes)
- Follow-up
- Median 9.0 years
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Incident CMM
Adjusted hazard ratio (95 % CI)
Low eGDRvs High eGDR
1.67(1.33–2.09)
High hsCRPvs Low hsCRP
1.43(1.12–1.82)
Low eGDR plus high hsCRPvs High eGDR plus low hsCRP
2.40(1.77–3.27)
- Participants who developed cardiometabolic multimorbidity (CMM)
- 464 (6.7 %)
Observational data: associations, not effects.
Further findings
Prediction of CMM with addition of combined eGDR and hsCRP
- C-statistic, discriminatory power and risk reclassification significantly improved
- P < 0.001
Original publication
Estimated glucose disposal rate, high sensitivity C-reactive protein and cardiometabolic multimorbidity in middle-aged and older Chinese adults: A nationwide prospective cohort study. Diabetes Res Clin Pract. Published 15 October 2024. doi:10.
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