N-terminal Pro-B-Type Natriuretic Peptide and Risk for Diabetes Mellitus and Metabolic Syndrome
Authors' conclusion
NT-proBNP was inversely associated with odds of diabetes, MetS, and the MetS dysglycemia component. The metabolic implications of B-type natriuretic peptides appear important for glycemic homeostasis.
Study context
- Population
- Participants of the REGARDS study with baseline (2003–2007) and follow-up (2013–2016) examinations and baseline NT-proBNP measurement
- Participants
- 2,899 participants
- Exposure
- Higher vs lower NT-proBNP
- Outcome
- Incident diabetes, incident MetS and MetS components
- Follow-up
- Mean 9.4 years
Methodological detailslogistic regression, fully adjusted for demographics, risk and laboratory factors
- Logistic regression
- Fully adjusted for demographics, risk and laboratory factors
Main finding
As reported in the abstract
Incident diabetes · mean 9.4 years
Participants developing diabetes
310
2364 at risk
Fully adjusted OR per SD higher log NT-proBNP for incident diabetes
0.80
95% CI 0.69–0.93
Observational data: associations, not effects.
Further findings
Incident metabolic syndrome (MetS) · mean 9.4 years
- Participants developing MetS
- 361 (2059 at risk)
- Fully adjusted OR, highest vs lowest NT-proBNP quartile
- 0.59 (95% CI 0.37-0.92)
- Linear association with incident MetS not statistically significant
Incident dysglycemia (MetS component)
- Fully adjusted OR per SD log NT-proBNP
- 0.65 (95% CI 0.53-0.79)
- Not associated with other MetS components
Effect modification
- No effect modification by sex, race, age or BMI
Original publication
N-terminal Pro-B-Type Natriuretic Peptide and Risk for Diabetes Mellitus and Metabolic Syndrome. J Clin Endocrinol Metab. Published 4 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →