Muscle Function and Bone Strength in Children and Adolescents with Tall Stature
Authors' conclusion
Dynamic muscle functions relative to body mass are decreased in healthy untrained individuals with TS, unlike trained individuals with TS. Reduced mechanical stimulation may contribute to decreased cortical BMD and thickness at the tibia in this group.
Study context
- Population
- Children and adolescents with tall stature (TS)
- Participants
- 98 children
- Exposure
- Untrained children/adolescents with TS vs actively training basketball players with TS
- TSn = 63
- Basketball players (BPs)n = 35
- Outcome
- Dynamic muscle functions (relative muscle power Pmax/mass and force Fmax/body weight) by jumping mechanography; bone strength markers by pQCT and DXA in TS group
Main finding
As reported in the abstract
Z-scores of Pmax/mass and Fmax/body weight vs age- and sex-specific normative values
| Group | Value | Pmax/mass Z-score P | Fmax/body weight Z-score |
|---|---|---|---|
| TS | mean −1.28 ± 1.15 | p < 0.001 | −1.10 ± 1.06; p < 0.001 |
| BPs | mean 0.99 ± 1.15 | p < 0.001 | 0.64 ± 1.42; p < 0.05 |
Value
TSmean −1.28 ± 1.15
BPsmean 0.99 ± 1.15
Pmax/mass Z-score P
TSp < 0.001
BPsp < 0.001
Fmax/body weight Z-score
TS−1.10 ± 1.06; p < 0.001
BPs0.64 ± 1.42; p < 0.05
Observational data: associations, not effects.
Further findings
Bone strength Z-scores (pQCT, tibia) in TS
- Cortical bone mineral density (BMD) Z-score (mean ± SD)
- −0.78 ± 1.0; p < 0.001
- Cortical thickness Z-score (mean ± SD)
- −0.57 ± 1.12; p < 0.001
- Trabecular BMD Z-score, normal (mean ± SD)
- 0.31 ± 1.46; p = 0.14
- Stress-strain index, increased
- 1.93 ± 0.96; p < 0.001
DXA Z-scores in TS
- Lumbar spine BMD, increased
- 0.99 ± 1.22; p < 0.001
- Whole-body bone mineral content (BMC), increased
- 1.81 ± 1.04; p < 0.001
- Whole-body BMD, normal
- 0.19 ± 1.16; p = 0.24
Original publication
Muscle Function and Bone Strength in Children and Adolescents with Tall Stature. Horm Res Paediatr. Published 5 May 2026. doi:10.
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