Multi-trajectories of triglyceride-glucose index and lifestyle with Cardiovascular Disease: a cohort study
Authors' conclusion
Distinct multi-trajectories of TyG levels and lifestyle scores corresponded to differing CVD risks. The CVD risk caused by a high level TyG trajectory remained increased despite adopting healthier lifestyles. These findings underscored the significance of evaluating the combined TyG and lifestyle patterns longitudinally, and implementing early interventions to reduce CVD risk by lowering TyG levels.
Study context
- Population
- Participants from three health surveys of the Kailuan Study; lifestyle scores from smoking, alcohol, physical activity, sedentary behaviors and salt intake
- Participants
- 47,384 participants
- Exposure
- Multi-trajectories of triglyceride-glucose (TyG) levels and lifestyle scores vs lowest TyG/best lifestyle trajectory
- Outcome
- Incident CVD
- Follow-up
- Median 10.98 years
Methodological detailsgroup-based multi-trajectory model, Cox proportional hazard model
- Group-based multi-trajectory model
- Cox proportional hazard model
Main finding
As reported in the abstract
Each group vs group 3Hazard ratio (95% CI)
Group 5highest CVD risk
1.76(1.50–2.05)
Group 2
1.45(1.26–1.66)
Group 1
1.33(1.17–1.50)
Group 4
1.32(1.18–1.47)
- Participants who developed cardiovascular disease (CVD) events
- 3042
- Strokes
- 2481
- MIs
- 616
- Co-current stroke and MI
- 55
Observational data: associations, not effects.
Original publication
Multi-trajectories of triglyceride-glucose index and lifestyle with Cardiovascular Disease: a cohort study. Cardiovasc Diabetol. Published 13 December 2023. doi:10.
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