Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes
Authors' conclusion
This study provides evidence that diabetes and glycemic traits have a causal relationship with cardiac and aortic structural and functional remodeling, highlighting the importance of intensive glucose-lowering for primary prevention of cardiovascular diseases.
Study context
- Population
- Genetic variants for T1D, T2D, fasting insulin (FIns), fasting glucose (FGlu), 2hGlu and HbA1c; 96 cardiovascular MRI traits from six independent genome-wide association studies
- Comparison
- Genetic liability to T1D, T2D and glycemic traits (FIns, FGlu, 2hGlu, HbA1c) vs cardiovascular MRI traits
- Outcome
- Cardiac and aortic structure and function (96 cardiovascular MRI traits), inverse-variance weighted MR
Methodological detailsinverse-variance weighted primary analysis, Steiger filtering, sensitivity analyses: weighted median, MR-Egger, MR-PRESSO, multivariable Mendelian randomization (MR) adjusted for BMI
- Inverse-variance weighted primary analysis
- Steiger filtering
- Sensitivity analyses: weighted median, MR-Egger, MR-PRESSO
- Multivariable MR adjusted for BMI
Main finding
As reported in the abstract
- Genetic susceptibility to T1D associated with increased ascending aortic distensibility
- T2D associated with reduced diameter and areas of the ascending aorta and decreased distensibility of the descending aorta
- Higher FGlu and HbA1c associated with decreased diameter and areas of the ascending aorta
- Higher 2hGlu associated predominantly with reduced diameter of ascending and descending aorta
- Higher FIns associated with increased regional and global LV myocardial-wall thickness at end-diastole and regional peak circumferential strain of the LV
Original publication
Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes. Cardiovasc Diabetol. Published 8 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →