Mortality among older adults with osteoporotic vertebral fracture
Authors' conclusion
An apparent benefit of kyphoplasty on mortality among patients with vertebral fractures was not present after rigorous propensity matching, illustrating the importance of comparing similar individuals when evaluating observational data.
Study context
- Population
- US Medicare enrollees with osteoporotic vertebral fractures, 2017–2019 (mean age 81.1 ± 8.3 years; 85.8% female)analysed
- Participants
- 235,317 enrollees
- Exposure
- Kyphoplasty vs no kyphoplasty
- Outcome
- Mortality (risk of death), kyphoplasty vs controls (primary analyses: group 1 and group 2)
Methodological detailspropensity-score matched, post hoc matched analyses
- Propensity-score matched
- Post hoc matched analyses
Main finding
As reported in the abstract
Mortality (primary analyses)
Adjusted hazard ratio (95% CI)
Kyphoplastyvs Group 1
0.84(0.82–0.87)
Kyphoplastyvs Group 2
0.88(0.85–0.91)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Mortality (post hoc matched analyses)Kyphoplastyvs Group 3Post hoc analyses | 1.32 (1.25–1.41) | |
| Mortality (post hoc matched analyses)Kyphoplastyvs Group 4Post hoc analyses | 1.81 (1.58–2.09) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Mortality among older adults with osteoporotic vertebral fracture. Osteoporos Int. Published 26 May 2023. doi:10.
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