Mitochondrial sourcing of interferogenic ligands and an autoantigen in human obesity‐associated metaflammation
Authors' conclusion
Interferogenic ligands and an autoantigen can be sourced from dysfunctional mitochondria in VAT of humans with obesity. Further therapeutic and prognostic potential for this immune mechanism in obesity warrants exploration.
Study context
- Population
- Patients with obesity and lean patients/patients without obesity; Visceral adipose tissue (VAT) samples and venous plasma
- Comparison
- Patients with obesity vs lean patients / without obesity
- Outcome
- Interferogenic ligands and autoreactivity
Methodological detailsVAT samples (gene expression, adipose explant cultures): obesity n = 54, lean n = 10, Venous plasma for autoantibody ELISA: with obesity n = 114, without obesity n = 45, Human pDC cultures treated with explant supernatants; interferon α ELISA
- VAT samples (gene expression, adipose explant cultures): obesity n = 54, lean n = 10
- Venous plasma for autoantibody ELISA: with obesity n = 114, without obesity n = 45
- Human pDC cultures treated with explant supernatants; interferon α ELISA
Main finding
As reported in the abstract
- MtDNA from VAT in obesity, in complex with mitochondrial transcription factor A protein (TFAM), acts as interferogenic ligands for plasmacytoid dendritic cells (pDCs)
- Humoral autoreactivity against TFAM is induced in obesity
Original publication
Mitochondrial sourcing of interferogenic ligands and an autoantigen in human obesity‐associated metaflammation. Obesity (Silver Spring). Published 26 July 2023. doi:10.
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