Associations of objectively measured physical activity, sedentary time and cardiorespiratory fitness with adipose tissue insulin resistance and ectopic fat
Authors' conclusion
Sedentary time is positively associated with adipose tissue insulin resistance which regulates lipogenesis and lipolysis. CRF is independently related to central fat storage which is a key risk factor for cardiometabolic disease.
Study context
- Population
- Community volunteers; male 60%, median (IQR) age 37 (19) years, body mass index (BMI) 26.1 (6.3) kg·m-2
- Participants
- 141 community volunteers
- Exposure
- Associations of sedentary time, MVPA and cardiorespiratory fitness (CRF) with Adipo-IR and ectopic fat
- Outcome
- Adipose tissue insulin resistance (Adipo-IR) and magnetic resonance imaging (MRI)-measured liver fat, VAT and ScAT
Methodological detailspooled data from two previous experimental studies, accelerometer-measured activity, generalized linear models
- Pooled data from two previous experimental studies
- Accelerometer-measured activity
- Generalized linear models
Main finding
As reported in the abstract
Sedentary time vs Adipo-IR, β (95% CI 0.27 to 1.10), P < 0.001
0.68 AU
Sedentary time vs VAT, β (95% CI 0.01 to 0.08), P = 0.005; stronger in females than males
0.05 L
CRF vs VAT, β (95% CI −0.04 to −0.01), P = 0.003; moderated by sex
−0.02 L
CRF vs ScAT, β (95% CI −0.13 to −0.06), P < 0.001; moderated by BMI
−0.10 L
Observational data: associations, not effects.
Original publication
Associations of objectively measured physical activity, sedentary time and cardiorespiratory fitness with adipose tissue insulin resistance and ectopic fat. Int J Obes (Lond). Published 25 July 2023. doi:10.
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