The visceral adipose tissue bacterial microbiota provides a signature of obesity based on inferred metagenomic functions
An erratum to this article was published (Int J Obes (Lond), Oct 2023 ↗)
Authors' conclusion
This innovative approach generates novel hypotheses regarding the gut to adipose tissue axis in obesity and notably the potential role of tissue microbiota.
Study context
- Population
- Patients with obesity; visceral adipose depot sampled
- Comparison
- Lean vs patients with obesity and people with severe obesity
- Outcome
- Visceral adipose tissue bacterial 16S rRNA gene signature
Methodological detailsCare (surgical, biochemical, bioinformatic) taken to avoid environmental contaminants; statistical discriminant analyses and interaction networks
- Care (surgical, biochemical, bioinformatic) taken to avoid environmental contaminants; statistical discriminant analyses and interaction networks
Main finding
As reported in the abstract
- Specific 16S rRNA gene signature of numerous bacterial families discriminated lean vs patients with obesity and people with severe obesity
- Main discriminant families: Burkholderiaceae, Yearsiniaceae and Xanthomonadaceae, all gram-negative
- Morganellaceae totally absent in people without obesity, preponderant in all patients with obesity
Further findings
Inferred metabolic pathways from 16S rRNA gene signatures
- Several pathways associated with adenosyl-cobalamine, previously linked with adipose tissue development
- Chorismate biosynthesis, involved in aromatic amino-acid metabolism, possibly playing a role in fat pad development
Original publication
The visceral adipose tissue bacterial microbiota provides a signature of obesity based on inferred metagenomic functions. Int J Obes (Lond). Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →